Training session 11
Negaplus
Category :
  • NEGAPLUS contains Cefoperazone
  • Cefoperazone is a semisynthetic third generation cephalosporin for parenteral use
  • Cefaperazone is a broad spectrum antibiotic and active against many beta lactamase producing microorganisms
  • Its activity against gram positive, gram negative and anaerobes makes Cefaperazone an ideal empirical treatment
Mechanism of action :
Cefixime is a beta lactam antibiotic. It inhibits the cell wall synthesis of the bacteria, thus killing the bacteria in the process.
Detailed mechanism of action
Absorption :
Cefoperazone is not meant for oral use. The drug is administered parenterally by IM or IV routes.
Higher peak serum levels are obtained when the drug is administered as an IV bolus injection
Distribution :
Protein binding is about 82-93%
Cefoperazone is widely distributed in body tissues and fluids. It must be noted that penetration of Cefoperazone into the CSF is poor.
The drug crosses the placenta. It is also excreted into breast milk.
Excretion :
Primary route of excretion is bile. The drug is also excreted unchanged through urine.
Microbiology :
Negaplus is useful in the management of infections caused by beta lactamase producing microorganisms
Gram Positive Organisms
Gram Negative Organisms
Anaerobes
  • Clostridium species
  • Bacteroides species
Indication and usage :
  • Respiratory tract infections
  • Intra-abdominal infections
  • Septicaemia
  • Bone and joint infections
  • Pelvic inflammatory disease
  • Urinary tract infections
Contraindications:
Known allergy to Cephalosporins.
Warnings :
In an individual allergic to beta lactam antibiotics, the probability of allergy manifestation to Cefixime cannot be ruled out.
Subsequent to the administration of Cefixime, patients who present with diarrhoea should be considered for diagnosis of pseudomembranous colitis.
Precautions :
In patients with severe biliary obstruction or severe liver disease with renal disease, the daily dose of Cefoperazone should not exceed 4 grams without close monitoring of serum levels
A disulfiram like reaction with flushing, sweating, headache and tachycardia has occurred when alcohol was administered within 24 hours or even upto 5 days after Cefoperazone injection.
Vitamin K deficiency has occurred in a few patients.
It is important to monitor the Prothrombin time when anticoagulants are used concomitantly.
Dosage:
2-4grams/ day in 2 equally divided doses, 12 hours apart. In severe infections doses upto 16grams/day have been administered without adverse side effects.
Paediatrics :
50-200mg/Kg/day in 2 equally divided doses, 12 hours apart. Upto 300mg/kg/day has been used in severe infections including meningitis.
Product formulation :
Cefoperazone for injection 1 gram
Benefits :
Negaplus has a broad spectrum and its activity against Gram-positive, Gram-negative and anaerobic pathogens . This truly broad spectrum and its activity even against beta lactamase producing strains makes Negaplus suitable for emperical treatment of infections caused by un identified pathogens.
Competition
Brand Company
CEFOMYCIN ZYDUS CADILA
MAGNAMYCIN PFIZER
MEGACEF BIOLOGICAL E
MYTICEF PANACEA
 
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