Training session 13
Orfix
Category :
  • ORFIX contains Cefixime
  • Cefixime is a broad spectrum, third generation cephalosporin for oral use. It has a bactericidal action.
  • Cefixime is stable against beta lactamase producing microorganisms.
Mechanism of action :
Cefixime is a betalactam antibiotic. It inhibits the cell wall synthesis of the bacteria, thus killing the bacteria in the process.
Detailed mechanism of action
Absorption :
After oral administration, 40-50% of a given dosage is slowly absorbed from the gastrointestinal tract.
65-70% of the drug is bound to plasma proteins.
Cefixime achieves high concentrations in the bile
Excretion :
The drug is excreted in the bile and urine.
Between 12-34% of the drug is excreted in the urine.
Upto 60% of the drug is eliminated by non renal mechanisms including biliary excretion
Microbiology :
  1. Enterobacteriaceae
  2. Haemophilus influenzae
  3. Neisseria gonorrhoeae (including penicillinase producing strains)
  4. Beta haemolytic streptococci
  5. Streptococcus pneumoniae
Indication and usage :
Cefixime is effective in the management of
Typhoid
Urinary tract infections
Upper and Lower respiratory tract infections
Gonococcal urethritis
Contraindications:
Known allergy to Cephalosporins.
Warnings :
In an individual allergic to beta lactam antibiotics, the probability of allergy manifestation to Cefixime cannot be ruled out.
Subsequent to the administration of Cefixime, patients who present with diarrhoea should be considered for diagnosis of pseudomembranous colitis.
Precautions :
  • Use with caution in patients with known allergy to penicillins and other cephalosporins.
  • Superinfection
  • Pseudomembranous colitis
  • Pregnancy and Lactation - The usage of Cefixime in Pregnancy has not been established. Cefixime is excreted in breast milk.
Adverse reactions :
Hypersensitivity
Rash, pruritus, erythema multiforme, Stevens Johnson syndrome, epidermal necrolysis
Haemotological
Haemolytic anaemia, leukopenia
Gastrointestinal
Nausea, Diarrhoea, dyspepsia, flatulence, abdominal pain, loose stools, flatulence, rarely pseudomembranous colitis
Genitourinary
Genital pruritus, candidiasis and Vaginitis
Dosage:
Adults:
200-400mg in single or divided doses
Paediatrics:
Under 50 kg - 8mg/kg bodyweight
Product Formulations:
Orfix is available as dispersible tablets of 100mg and Capsules of 100mg and 200mg.
Benefits :
Orfix is the most powerful typhoid terminator
Orfix is useful in the management of infections caused by beta lactamase producing microorganisms
Competition :
Brand
Company
Cefspan
Burroughs Wellcome
Taxim-O
Alkem
Topcef
Torrent
Ceftas
Intas
 
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